De Quervain’s syndrome is an irritation of two tendons that can result in pain and tenderness on the thumb side of the wrist. It occurs when the tendons at the wrist become irritated due to repeated hand or wrist movements. Pain is often reproduced with resisted movements of the thumb.

Arthritis of the thumb can result in pain, tenderness and/or stiffness at the base of the thumb. Patients often report difficulty with pinching and gripping, such as twisting a key, using scissors and opening jars. Patients often present with decreased mobility and strength at their thumb joint.